Table 2.
Protein hubs in TG Dyrk1A cerebellum network.
| Interactions (n) | Value of p | Symbol | Uniprot ID | Description | Rescued | Seed |
|---|---|---|---|---|---|---|
| 14 | 0.05806 | Casp3 | P70677 | Caspase 3 | Yes | |
| 13 | 0.06702 | Vamp2 | P63044 | Vesicle-associated membrane protein 2 | ||
| 13 | 0.06702 | Uqcrb | Q9D855 | Ubiquinol-cytochrome c reductase binding protein | ||
| 13 | 0.06702 | Arpc5 | Q9CPW4 | Actin related protein 2/3 complex, subunit 5 | Yes | |
| 13 | 0.06702 | Uqcrh | P99028 | Ubiquinol-cytochrome c reductase hinge protein | Yes | Yes |
| 13 | 0.06702 | Polr2c | P97760 | Polymerase (RNA) II (DNA directed) polypeptide C | Yes | |
| 12 | 0.07788 | Uqcrc1 | Q9CZ13 | Ubiquinol-cytochrome c reductase core protein 1 | Yes | Yes |
| 12 | 0.07788 | Pcna | P17918 | Proliferating cell nuclear antigen | Yes | Yes |
| 12 | 0.07788 | Polr2j | O08740 | Polymerase (RNA) II (DNA directed) polypeptide J | ||
| 12 | 0.07788 | Uqcr10 | Q8R1I1 | Ubiquinol-cytochrome c reductase, complex III subunit X | Yes | |
| 12 | 0.07788 | Arrb1 | Q8BWG8 | Arrestin, beta 1 | ||
| 12 | 0.07788 | Itsn1 | Q9Z0R4 | Intersectin 1 (SH3 domain protein 1A) | ||
| 11 | 0.0912 | Cox6c | Q9CPQ1 | Cytochrome c oxidase subunit 6C | Yes | Yes |
| 11 | 0.0912 | Cyc1 | Q9D0M3 | Cytochrome c-1 | Yes | Yes |
| 11 | 0.0912 | Uqcrc2 | Q9DB77 | Ubiquinol cytochrome c reductase core protein 2 | Yes | Yes |
| 11 | 0.0912 | Ndufb10 | Q9DCS9 | NADH:ubiquinone oxidoreductase subunit B10 | Yes | Yes |
| 11 | 0.0912 | Ndufs8 | Q8K3J1 | NADH:ubiquinone oxidoreductase core subunit S8 | Yes | Yes |
| 11 | 0.0912 | Lrp2 | A2ARV4 | Low density lipoprotein receptor-related protein 2 | ||
| 10 | 0.10771 | Cox5a | P12787 | Cytochrome c oxidase subunit 5A | Yes | Yes |
| 10 | 0.10771 | M6pr | P24668 | Mannose-6-phosphate receptor, cation dependent | Yes | |
| 10 | 0.10771 | Ndufa1 | O35683 | NADH:ubiquinone oxidoreductase subunit A1 | Yes | Yes |
| 10 | 0.10771 | Csnk1d | Q9DC28 | Casein kinase 1, delta | Yes | |
| 10 | 0.10771 | Plk1 | Q07832 | Polo like kinase 1 | ||
| 10 | 0.10771 | Ikbkb | O88351 | Inhibitor of kappaB kinase beta | ||
| 10 | 0.10771 | Prkar1a | Q9DBC7 | Protein kinase, cAMP dependent regulatory, type I, alpha | Yes | |
| 10 | 0.10771 | Cttn | Q60598 | Cortactin | ||
| 9 | 0.12845 | Birc3 | O08863 | Baculoviral IAP repeat-containing 3 | ||
| 9 | 0.12845 | Crebbp | P45481 | CREB binding protein | ||
| 9 | 0.12845 | Cox4i1 | P19783 | Cytochrome c oxidase subunit 4I1 | Yes | Yes |
| 9 | 0.12845 | Pacsin1 | Q61644 | Protein kinase C and casein kinase substrate in neurons 1 | ||
| 9 | 0.12845 | Pacsin3 | Q99JB8 | Protein kinase C and casein kinase substrate in neurons 3 | Yes | |
| 9 | 0.12845 | Xiap | Q60989 | X-linked inhibitor of apoptosis | ||
| 9 | 0.12845 | Pacsin2 | Q9WVE8 | Protein kinase C and casein kinase substrate in neurons 2 | ||
| 9 | 0.12845 | Birc2 | Q62210 | Baculoviral IAP repeat-containing 2 | ||
| 9 | 0.12845 | Creb1 | Q01147 | camp responsive element binding protein 1 | Yes | |
| 8 | 0.1549 | Tnfrsf1a | P25118 | Tumor necrosis factor receptor superfamily, member 1a | ||
| 8 | 0.1549 | Rpl28 | P41105 | Ribosomal protein L28 | Yes | |
| 7 | 0.18922 | Ranbp2 | Q9ERU9 | RAN binding protein 2 | ||
| 7 | 0.18922 | Prkaca | P05132 | Protein kinase, cAMP dependent, catalytic, alpha | ||
| 7 | 0.18922 | Mylk | Q6PDN3 | Myosin, light polypeptide kinase | ||
| 7 | 0.18922 | Rhoq | Q8R527 | Ras homolog family member Q | ||
| 7 | 0.18922 | Chuk | Q60680 | Conserved helix-loop-helix ubiquitous kinase | ||
| 7 | 0.18922 | Baiap2 | Q8BKX1 | Brain-specific angiogenesis inhibitor 1-associated protein 2 | Yes | Yes |
| 7 | 0.18922 | Ndufs5 | Q99LY9 | NADH:ubiquinone oxidoreductase core subunit S5 | Yes | Yes |