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. 2022 Nov 24;28(12):2547–2554. doi: 10.1038/s41591-022-02075-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Schematic of the quantified peptides of t-tau 212–221, truncation and 4R isoform-specific MTBR-tau in the R2 region (gray bars, MTBR-tau₂₇₅ and MTBR-tau₂₈₂). The relative abundance of each MTBR-tau was normalized to the t-tau peptide. b,c, CSF MTBR-tau₂₇₅/t-tau (b) and MTBR-tau₂₈₂/t-tau (c) significantly decreased in CBD (n = 18), AD (n = 10) and FTLD-MAPT (n = 5) compared to normal control (n = 29), FTLD-TDP (n = 21) and other FTLD-tau. FTLD-MAPT P301L (red, n = 2), R406W (blue, n = 2) and S305I (green, n = 1) decreased in MTBR-tau/t-tau measurements in this order. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. The box plots show the minimum, 25th percentile, median, 75th percentile and maximum. Differences in biomarker values were assessed with a one-way ANOVA. A two-sided P < 0.05 was considered statistically significant and corrected for multiple comparisons using a Benjamini–Hochberg FDR set at 5%.