Fig. 3. CSF soluble MTBR-tau correlates with brain insoluble MTBR-tau aggregates.

a,b, MTBR-tau₂₇₅/t-tau (a) and MTBR-tau₂₈₂/t-tau (b) from paired CSF and brain inversely correlated in tauopathies, FTLD-TDP and control (n = 54, r = −0.27, P = 0.049, −0.45, P = 0.0006, respectively). c,d, MTBR-tau₂₇₅/t-tau (c) and MTBR-tau₂₈₂/t-tau (d) from paired CSF and brain had higher correlations (r = −0.61, P = 0.0004 and r = −0.75, P < 0.0001, respectively) in 4R tauopathies (CBD, PSP and AGD, n = 29). e,f, MTBR-tau₂₇₅/t-tau (e) and MTBR-tau₂₈₂/t-tau (f) from paired CSF and brain correlated in CBD (n = 12, r = −0.25, P = 0.43 and r = −0.31, P = 0.33, respectively). The gray shadow represents the 95% confidence intervals for the linear regression.