Table 1.
Demographics and brain MTBR-tau measures of participants in the primary tauopathy cohort
| Group | Normal control | FTLD-TDP | PiD | AGD | PSP | CBD | AD | FTLD-MAPT | Total |
|---|---|---|---|---|---|---|---|---|---|
| n | 3 | 12 | 3 | 1 | 16 | 12 | 7 | 8 | 62 |
| Pure pathology | N/A | 5 | 3 | 0 | 9 | 7 | 7 | 6 | 37 |
| Copathology (n) | N/A | AD (1), AGD (1), HS + vascular (1), MND (4) | N/A | Vascular (1) | AD (4), LBD (2), vascular (1) | AD (3), PSP (1), LBD (1) | N/A | AD (1), HS (1) | 22 |
| Age at death, years | 81 ± 5 | 68 ± 11 | 70 ± 3 | 68 | 76 ± 7 | 69 ± 8 | 61 ± 6 | 63 ± 11 | 69 ± 10 |
| Sex, M/F | 1/2 | 8/4 | 1/2 | 1/0 | 6/10 | 5/7 | 4/3 | 5/3 | 31/31 |
| Brain region (SFG/insula) | 1/2 | 12/0 | 3/0 | 1/0 | 16/0 | 12/0 | 7/0 | 2/6 | 54/8 |
| Brain MTBR-tau275/t-tau, SD | 0.235 ± 0.053 | 0.213 ± 0.066 | 0.226 ± 0.110 | 0.200 | 0.489 ± 0.229 | 1.078 ± 0.346 | 0.319 ± 0.047 | 0.762 ± 0.333 | 0.536 ± 0.388 |
| Brain MTBR-tau282/t-tau, SD | 0.382 ± 0.097 | 0.348 ± 0.133 | 0.327 ± 0.151 | 0.294 | 0.789 ± 0.368 | 1.736 ± 0.760 | 0.915 ± 0.180 | 1.128 ± 0.512 | 0.895 ± 0.646 |
HS, hippocampal sclerosis; LBD, Lewy body dementia; MND, motor neuron disease.