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. 2022 Dec 8;28(12):2521–2529. doi: 10.1038/s41591-022-02100-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Duration of VILPA bout up to 1 minute (A); Duration of VILPA bouts up to 2 minutes (B); Frequency of length-standardized VILPA bouts up to 1 minute (C); and Frequency of length-standardized VILPA bouts up to 2 minutes (D). Participants with no VILPA were the reference category. The remaining categories are based on VILPA tertiles. Analyses adjusted for age, sex, duration of light intensity physical activity, duration of moderate intensity physical activity, smoking history, alcohol consumption, accelerometer estimated sleep duration, fruit and vegetable consumption, education, self-reported parental history of cardiovascular disease and cancer, and self-reported medication use (cholesterol, blood pressure, and diabetes), and prevalent cancer and CVD. All analyses were additionally adjusted for vigorous physical activity duration/bouts lasting more than one/two minutes, as appropriate. See Online Methods for further details on the statistical methodology. Sample size = 25,241; events = 868. Error bars represent 95% CI.