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. 2022 Dec 8;28(12):2573–2583. doi: 10.1038/s41591-022-02126-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–d, PFS assessed according to iRECIST in the PP population (a), the PD-L1^positive (b) and PD-L1^negative (c) PP population subsets and the FAS (d). e, OS in the FAS. f, Time to deterioration (reduction ≥20 points) of the global health status/quality of life score in the EORTC QLQ-C15-PAL questionnaire. The analysis includes the 62 patients (91%) in the FAS for whom a baseline value was available. The proportions of patients who completed this item at each of the subsequent timepoints are available in Extended Data Table 4. HRs with CIs were estimated using the Cox proportional hazards method. P values were calculated by the log-rank method.