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. 2022 Dec 1;28(12):2555–2562. doi: 10.1038/s41591-022-02074-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — Log10-transformed plasma biomarker levels were compared between the CSF Aβ42/40 quintile groups, Q1 ( > 0.102; median [MD], 0.108; n = 115, reference group), Q2 (range, 0.089-0.102; MD, 0.097; n = 115), Q3 (range 0.064-0.089; MD, 0.079; n = 115), Q4 (range, 0.042-0.064; MD, 0.051; n = 115) and Q5 (range, <0.042; MD, 0.035; n = 115) using univariate general linear models adjusting for age. Untransformed data are presented in the boxplots to aid interpretation of biomarker values across different comparisons. Outliers (p-tau217, n = 1; p-tau181, n = 2; GFAP, n = 1; NfL, n = 2) are not shown in the boxplots but were included in the statistical analysis. Boxes show interquartile range, the horizontal lines are medians, and the whiskers were plotted using Tukey method. Two-sided p-values were corrected for multiple comparisons using Benjamini–Hochberg false discovery rate; uncorrected and corrected p-values are shown in Extended Data Table 6.