Table 1.
Associations of Aβ status with longitudinal plasma biomarker levels in BioFINDER-1 and WRAP
| BioFINDER-1 Cognitively unimpaireda | BioFINDER-1 Mild cognitive impairmenta | WRAP Cognitively unimpairedb | |
|---|---|---|---|
| Plasma biomarkers | Time × Aβ interaction β estimate (P value) | ||
| p-tau231 | −0.002 (0.946) | −0.063 (0.437) | −0.001 (0.951) |
| p-tau217 | 0.249 (3.8 × 10−13) | 0.270 (0.0005) | 0.103 (5.4 × 10−8) |
| p-tau181 | 0.073 (0.066) | 0.050 (0.384) | 0.047 (0.036) |
| Aβ42/40 | 0.007 (0.841) | −0.076 (0.165) | −0.019 (0.345) |
| GFAP | 0.028 (0.084) | 0.113 (0.065) | 0.023 (0.273) |
| NfL | 0.035 (0.246) | 0.084 (0.177) | −0.039 (0.273) |
β estimates and P values are from linear mixed effects models with the interaction between time and Aβ status as the independent variable, adjusted for age and sex. Two-sided P values were adjusted for multiple comparisons (n = 24, BioFINDER-1; n = 12, WRAP) using Benjamini–Hochberg FDR. Data tables with uncorrected P values are displayed in Supplementary Table 1.
a Aβ42/40 data were available for 130 CU and 82 MCI; GFAP data were available for 124 CU and 82 MCI; NfL data were available for 125 CU and 82 MCI in BioFINDER-1. bData values for two participants were missing for p-tau231, p-tau181, Aβ42/40, GFAP and NfL in WRAP.