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. 2022 Dec 1;28(12):2633–2645. doi: 10.1038/s41591-022-02059-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, CLNA043X2101 study design summarizing the study periods and treatment arms. The end of study visit was at day 36 for cohorts 1–4 and 7, at day 29 for cohort 5 and at day 50 for cohort 6. b, CONSORT diagram showing the flow of patients at each stage of the FIH trial. c, Baseline data and demographics. BMI, body mass index.