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. 2022 Dec 16;13:1081553. doi: 10.3389/fphar.2022.1081553

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Copyright © 2022 Li, Zhuge, Wang, Xia, Wang, Han, Shen and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OCA and Fer-1 differentially reshaped intestinal microbiome. (A) alpha diversity indexes (Chao1 and dominance) of five groups. (B) Principal coordinates analysis (PCoA) based on weighted UniFrac distances. (C) Relative abundance of altered taxa at the family (F) and genus (G) levels. (E–F) LEfSe cladogram represents the taxa enriched in the groups. (G) Taxa with significant differences between the AMLN diet group with OCA group. (H) Taxa with significant differences between the AMLN diet group with Fer-1 group. Data are shown as mean ± SEM (D).