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. 2022 Dec 16;13:1081553. doi: 10.3389/fphar.2022.1081553

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Copyright © 2022 Li, Zhuge, Wang, Xia, Wang, Han, Shen and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OCA and Fer-1 differentially modulated hepatic lipidome. (A) Principal Component Analysis between the five groups. (B) Relative abundance (%) of lipid subclass among five groups (C) The ratio of PC/PE. (D) Relative abundance of PC (left) and TAG (right). (E) Relative abundance of ω-3 PUFA -rich TAG (left) and ω-6 PUFA -rich TAG (right). (F) Relative abundance of PC (left) and TAG (right) with different amount of double bonds. (G) The top 15 most significant lipids between groups. Data are shown as mean ± SEM. *p < 0.05.