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. 2022 Dec 16;12:1073036. doi: 10.3389/fonc.2022.1073036

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Copyright © 2022 Solár, Mackerle, Hendrych, Pospisil, Lakomy, Valekova, Hermanova and Jancalek

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Case report 1: (A) preoperative axial MRI (postcontrast T1 weighted image) showing an intra-axial contrast-enhancing lesion in the left parietal lobe with perilesional edema extending to the central region, (B) histopathological finding of hypercellular pleomorphic glial neoplasia with multiple palisading necroses and glomeruloid microvascular proliferations (H&E, original magnification 100x), (C) postoperative MRI showing subtotal tumor resection, (D) GBM recurrence 5 months after primary tumor resection, (E) 2 years follow-up MRI, and (F) MRI with second tumor recurrence (arrow) 61 months after the first GBM recurrence.