Table 2.
Influence of key mutations on the kinase and ATPase activities of select BY-kinases
| BY-kinase | Mutations | ATPase activity | Kinase activity | Reference |
|---|---|---|---|---|
| Bacillus subtilis YwqD | D81A, D83A (Walker-A′) | Greatly reduced | Abolished | Mijakovic (45) |
| Y225F/Y227F/Y228F (Y-cluster) | Enhanced | N/A | Mijakovic (45) | |
| Sinorhizobium meliloti ExoP | G588V, G588E, K589I (Walker-A) | Abolished | Abolished | Niemeyer (44) |
| E. coli K-12 Wzc | D562A, D564A (Walker-A′) | Reduced | Reduced | Soulat (43) |
| Y569N, Y569F | Reduced | Reduced | Soulat (43) | |
| K540M (Walker-A) | Abolished (Hajredini) | Reduced (Bechet) |