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. 2022 Dec 16;13:975066. doi: 10.3389/fphar.2022.975066

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Copyright © 2022 Yu, Liu, Du, Chen, Zhao, Zhou, Wang, Zheng, Bergen, Li, Sun, Fang, Li, Fan, Wu, Guo, Li, Yu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Goodness-of-fit plots for the final population PK model. Predicted concentrations are in micrograms per liter and time is in hours. (A) PPK model schematic figure and final model, DIS = 1 for patients and DIS = 2 for healthy subjects; (B) Observed polymyxin B concentrations (DV) versus population predictions (PRED). (C) DV versus individual predictions (IPRED). (D) Log transformed DV versus Log transformed IPRED. (E) Conditional weighted residuals (CWRES) versus PRED. (F) Conditional individual weighted residuals (CIWRES) versus IPRED. (G) Log transformed DV versus Log transformed PRED. (H) CWRES versus time after dose (TAD). (I) distribution of CWRES.