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. 2022 Dec 16;13:975066. doi: 10.3389/fphar.2022.975066

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Copyright © 2022 Yu, Liu, Du, Chen, Zhao, Zhou, Wang, Zheng, Bergen, Li, Sun, Fang, Li, Fan, Wu, Guo, Li, Yu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Probability of target attainment for different dosage regimens of polymyxin B against common carbapenem-resistant organisms according to PK/PD simulations. (A) Loading dose for three bacterial species. (B) K. pneumoniae (KP), (C) P. aeruginosa (PA), (D) A. baumannii (AB); The fAUC_ss,24h/MIC targets were 13.5 for a 1-log₁₀ reduction against K. pneumoniae and 17.6 and 17.4 for a 2-log₁₀ reduction against P. aeruginosa and A. baumannii, respectively. The unbound fraction in plasma was .42.