TABLE 4.

Pharmacokinetic parameters by non-compartmental analysis.

Parameter	Unit	Mean value ± SD
Cmax	mg/L	5.42 ± 1.69
AUC12h *	mg·h/L	39.8 ± 12.5
Cavg	mg/L	3.35 ± 1.06
T1/2	h	12.5 ± 3.11
CL	L/kg/h	0.028 ± 0.007
Vd	L/kg	0.490 ± 0.142

SD, standard deviation; AUC_12h, area under the concentration-time curve across 12 h; Cavg, average concentration; T1/2, half-life; CL, clearance; Vd, volume of distribution. All values are calculated at steady state.

^*The corresponding AUC_24h (area under the concentration-time curve across 24 h) is 79.6±25.0 mg h/L.