TABLE 5.
Population pharmacokinetic parameter estimates and between-subject variability.
| Parameter (Unit) | Estimate | Between-subject variability | ||
|---|---|---|---|---|
| Original dataset (Typical value) | Bootstrap dataset (Median and 95% interval confidence) | Original dataset (%) | Bootstrap dataset (%) | |
| CL (L/h) | 1.60 | 1.60 (1.5, 1.7) | 18.2 | 17.7 |
| V1 (L) | 38.6 | 38.6 (27.7, 54.4) | 20.0 | 18.7 |
| V2 (L) | 7.13 | 7.04 (5.93, 7.98) | 27.2 | 25.6 |
| Q (L/h) | 3.45 | 3.39 (2.31, 4.48) | 0 (FIX) | — |
| θDIS on V1 | 0.371 | 0.372 (0.31, 0.45) | NA | NA |
| θAGE on V2 | 1.67 | 1.68 (1.34, 1.95) | NA | NA |
| Proportional error (%) | 11.8 | 11.6 (10.4, 12.9) | NA | NA |
CL, clearance from the central compartment; V1, central volume of distribution; V2, peripheral volume of distribution; Q, intercompartmental clearance.