Table 1.

The prognostic role and functions of several representative metalloproteinases involved in pan-cancers.

Type of MP	Representatives	Cancers	Prognostic role	Functions	References
Matrix Metalloproteinase (MMPs)	MMP2	Most types of cancer	Decreasing OS	Degrading collagen and extracellular matrix; Involving TGF-β signaling pathway; Increasing cytokine production; Enhancing cancer cell invasiveness; Promoting angiogenesis;	(24–37)
	MMP9	Most types of cancer	Decreasing OS	Degrading collagen and extracellular matrix; Involving TGF-β signaling pathway; Facilitating the migration of immune cell; Hydrolyzing cytokines; Promoting cancer migration, invasiveness and metastasis; Promoting angiogenesis;	(24–29, 31–35, 38–50)
	MMP14	Ovarian cancer, Breast cancer, etc.	Decreasing OS	Degrading extracellular matrix; Cleaving and activating cytokines; Activating metalloproteinase; Promoting angiogenesis;	(27–29, 31–35, 39, 51)
A Disintegrin and Metalloprotease (ADAMs)	ADAM10	Lung cancer, glioma, head and neck squamous cell carcinoma(HNSCC), etc.	Most in decreasing OS (controversy in HNSCC)	Involving Notch signaling pathway; Involving formation of cancer-associated fibroblasts; Regulating immune cells; Inhibiting antitumor immunity;	(13, 52–69)
	ADAM17	Most types of cancer	Decreasing OS	Involving TNF and Notch signaling pathway; Regulating immune cells; Regulating cytokines; Inhibiting antitumor immunity;	(12, 13, 53, 54, 58–63, 67, 68, 70–78)
ADAMs with Thrombospondin Motifs (ADAMTS)	None	Many cancers	Uncertainty	Dual function (Promoting and inhibiting cancer progression)	(79–82)