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Engineering of a Cre/Lox mouse that allows for ubiquitous coexpression of p21 and tdTomato. (A) Schematic representation of transgenes used for Cre expression (Hprt-Cre) and Cre-inducible expression of p21 (LSL-p21 for LoxP/STOP/LoxP-p21) and tdTomato (Ai14). (B–C) tdTomato and p21 expression across tissues assessed by RT-qPCR (n = 4/group). Data represent means ± SD. ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001, as assessed by unpaired two-tailed t tests.
