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. 2022 Dec 9;67:101652. doi: 10.1016/j.molmet.2022.101652

Figure 3.

Figure 3

p21 induces a transcriptional program in skeletal muscle consistent with cellular senescence. (A-B) Enriched senescence-related pathways in p21OE mice identified by GSEA via RNA-seq of the quadriceps muscle (n = 3/group). (A) Curated senescence-related pathways. (B) KEGG pathways. Gene sets enriching SenMayo, SASP, NF-κB, p53 signaling, cytokine–cytokine receptor interaction, and cytosolic DNA sensing pathway are visualized via colored gene nodes and edges to illustrate the relationships between genes within a given pathway. The colors of gene nodes and edges are scaled to an interaction score and network category, respectively. # denotes false discovery rate (FDR) q value < 0.25.