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. Author manuscript; available in PMC: 2023 Dec 30.
Published in final edited form as: Alzheimers Dement. 2022 Jun 30;19(3):896–908. doi: 10.1002/alz.12719

Figure 2.

Figure 2.

Figure 2.

Figure 2.

Genetic association of Alzheimer disease (AD) with MGMT in the ADGC datasets (A and B) and in the Hutterites (C). A. Locus-zoom plot showing the association of AD with SNPs in the MGMT region in the ADGC datasets. The SNP with the lowest P-value (rs12775171) is indicated with a purple diamond. Computed estimates of linkage disequilibrium (r2) of SNPs in this region with rs1277517 are color-coded according to the key. B. Forest plot of the association of AD with rs12775171 among the APOE ε4- women within each ADGC dataset and in the toal sample (META). The ADGC-8 dataset includes eight individual GWAS datasets (ACT2, BIOCARD, CHAP2, EAS, NBB, RMAYO, UKS, and WASHU2) each containing < 50 subjects. The odds ratio (shaded symbol) and 95% confidence interval (represented by horizontal line) are plotted on the x-axis. C. Locus-zoom plot showing the association of AD with SNPs in the MGMT region in the Hutterites. Significance level is shown as the -log10(p-value). Computed estimates of linkage disequilibrium (r2) of SNPs in this region with the two most significant SNPs, rs12256016 (left panel) and rs2803456 (right panel), are color-coded according to the key. Recombination rates among adjacent SNPs are indicated with vertical blue lines.