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. 2023 Jan 1;13(1):417–437. doi: 10.7150/thno.77694

Figure 8.

Figure 8

The regulatory function of WWP1 on cardiac ischemic injury post-MI is dependent on KLF15. Mice were injected with rAAV9-cTnT-WWP1 with or without rAAV9-cTnT-KLF15 before they subjected to MI. A-C Cardiac function indices were measured by echocardiography at day 3 post-MI. n = 6. D-H mRNA levels of IL-6, IL-1β, TNF-α, VCAM-1, and MCP-1 in infarcted or healthy hearts were tested by qRT-PCR at day 3 post-MI. n = 4. I-K Cardiac function indices were measured by echocardiography at day 21 post-MI. n = 6. L Ratio of heart weight/ body weight (HW/BW). n = 6. M-Q qRT-PCR was used to test the mRNA levels of ANP, BNP, β-MHC, collagen I, collagen III. n = 3. R, S Sirius red staining were performed to detect fibrosis. n = 4. The data are shown as the means ± SD. The data shown in B-H, J-Q, and S were analysed by one-way ANOVA followed by Bonferroni post hoc test.