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. 2023 Jan 1;13(1):1–15. doi: 10.7150/thno.73966

Figure 3.

Figure 3

Transdermal delivery of CpG-NPs using MNs reduces tumor growth and increases survival in a murine model of orthotopic melanoma. A, Five days post tumor implantation, orthotopic tumors were treated with MNs loaded with CpG-NPs (1 µg CpG-ODN delivered/patch), CpCCtrl-NPs (1 µg CpC-ODN delivered/patch) or empty MNs. MNs were applied on top of the tumor every three days for five cycles (q3dx5). B; Tumor growth in B16-F10 melanoma-bearing mice (n = 8-10, data are mean ± s.e.m.). C, Kaplan-Meier curves of humane survival. Statistical significance was determined between groups by the Mantel-Cox test. ***P < 0.001, **P < 0.01, *P < 0.05. D, Individual tumor growth curves of empty MNs, CpCCtrl-NP MNs, and CpG-NP MNs treatment groups (n = 8-10 biologically independent samples).