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. 2023 Jan 1;13(1):231–249. doi: 10.7150/thno.78878

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SIRT6 dramatically regulates macrophage efferocytosis under high glucose conditions. (A) The phagocytic index was assessed by Immunofluorescence and flow cytometry. Efferocytosis was assessed in macrophages induced by THP-1 with CFSE-labelled autologous cell-tracker (red)-tagged apoptotic neutrophils (B) Mitochondrial NAD⁺/NADH ratio detected by NAD⁺/NADH Assay Kit with WST-8. (C) The expression of Sirtuins in macrophages after High glucose stimulation. (D) Co-staining of CD68, as a marker for macrophages, and SIRT6 in the gingivae of periodontitis and those with diabetic periodontitis (E-F) Phagocytic index of macrophages after SIRT6 inhibit and overexpression. The results were presented as means ± S.D. *p < 0.05; **p < 0.01; ***p > 0.001 by ANOVA or Student's t test.