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. 2023 Jan 1;13(1):231–249. doi: 10.7150/thno.78878

Figure 8.

Figure 8

Local delivery of antagomir-217 promotes the resolution of inflammation in mice DP. (A) Schematic diagram of the LIP and LIP resolution models and treatment schedule induction. (B) Representative 3D micro-CT scanning images and reconstructed sections in LIP and LIP resolution of NC and antagomir-217 treatment mice. Arrowhead: the area of loss of alveolar bone. (C) Representative images of TRAP-stained paraffin sections in the periodontium of NC and antagomir-217 treatment mice. (D) Representative images of the expression of DEL-1 in the periodontium of NC and antagomir-217 treatment mice. (E) Representative images of Ly6g positive neutrophils in the periodontium of NC and antagomir-217 treatment mice. (F) Representative images of TUNEL staining in the periodontium of NC and antagomir-217 treatment mice. (G-P) Quantification of the distance of CEJ-ABC, OC. N/ BS and OC. S/BS, the expression of DEL-1 and CD36, neutrophils, TUNEL positive apoptotic cells, NET, macrophage infiltration, and M1 and M2 polarization (n = 5 mice in the NC group and n = 5 mice in antagomir-217 groups). The results were presented as means ± S.D. *p < 0.05; **p < 0.01; #p > 0.05 by ANOVA or 2-tailed, unpaired Student's t test. T: Tooth, B: Bone of Alveolar, 14DL: 14 days ligated; 7DL-7DR: 7 days ligated and 7 days with ligatures removed. The white dotted line indicates the boundary between the root and the alveolar bone and the gingiva.