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. 2023 Jan 1;13(1):197–230. doi: 10.7150/thno.79535

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Schematic illustration of correlation between REST, CTCF and their interaction proteins and selected epigenetic markers. (A) Epigenetic markers of the genes related to neural and stem cells are recruited from http://dbtoolkit.cistrome.org, and the mode diagram was drawn using Goplot R package; (B) The mode diagram was drawn using Circlize R package.CHD8: Chromodomain Helicase DNA Binding Protein 8; CREBBP: CREB Binding Protein; CTDSP1: Carboxy-terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 1; DDX5: DEAD-Box Helicase 5; EP300: E1A Binding Protein P300; EED: Embyonic Ectoderm Development; FBXW7: F-Box And WD Repeat Domain Containing 7; HDAC2: Histone Deacetylase 2; HIST1H2BD: Histone Cluster 1 H2BD; HIST1H2BH: Histone Cluster 1 H2BH; HIST1H2BJ: HistoneCluster1 H2BJ; HTT: Huntingtin; KAT2A: Lysine Acetyltransferase 2A; KDM1A: Lysine Demethylase 1A: MBD2: Methyl-CpG Binding Domain Protein 2; MTA2: Metastasis Associated 1 Family member2; MYC: Myc Proto-Oncogene, BHLH Transcription factor; NANOG: Nanog Homeobox; NCOR1: Nuclear Receptor Corepressor 1; NIPBL: NIPBL Cohesion Loading factor; NPM1: Nucleophosmin 1; POU5F1: POU Class 5 Homeobox 1; RAD21: RAD21 Cohesion Complex Component; RB1: RB Transcriptional Corepressor 1; RBL2: RB Transcriptional Corepressor Like 2; RCOR1: REST Corepressor 1 (CoREST); SAP30: SIN3A Associated Protein 30; SIN3A: SIN3 Transcrition Regulatory Family Member A; SIN3B: SIN3 Transcrition Regulatory Family Member B; SKP2: S-Phase Kinase Associated Protein 2; SMC3: Structural Maintenance Of Chromosomes 3; SNAI1: Snail Family Transcriptional Repressor 1; STAG2: Stromal Antigen 2; SUZ12: SUZ12 Polycomb Repressive Complex 2 Subunit; TP53: Tumor Protein P53; YY1: YY1 Transcription Factor.