Figure 1.
Viability, SSTR2 protein levels, and [68Ga]Ga-DOTA-TATE uptake of MPC and MTT cells treated with epigenetic drugs; (A) Sequence of investigations after treatment with VPA and DAC as single and combination doses with different concentrations; (M) measurements; (B) Dose-response-curves showing reduction of cell viability in response to increasing concentrations of epigenetic drugs; dose ranges of DAC (dashed area) and VPA (dotted area) for investigations on SSTR2 modulation: (C) Western-Blot analysis showing changes in SSTR2 protein levels of cells upon ET; relative quantity: SSTR2/ACTB ratio normalized to the average of MTT [Controls]; (D) SSTR2 radioligand assay showing changes in [68Ga]Ga-DOTA-TATE uptake of cells upon ET; significance of differences: * P < 0.05, ‡ P < 0.01, # P < 0.001.