Table 3.
MPC tumors | [PRRT]↑↓ vs. [Control] (day 10) | [ET + PRRT]↑↓ vs. [Control] (day 10) | [ET]↑↓ vs. [Control] (day 4) | |||
---|---|---|---|---|---|---|
AV tumor 24h = 4.05 MBq/mL | AV tumor 24h = 4.48 MBq/mL | |||||
Extracted KEGG pathway | nes (fdr) | Leading-edge genes (top 10) | nes (fdr) | Leading-edge genes (top 10) | nes (fdr) | Leading-edge genes |
Central carbon metabolism in cancer | ↓ ‒1.5 (0.10) | ↓Pdk1, ↓Slc2a1 | ↑ 1.3 (0.23) | ↑Slc1a5 | ↑ 1.8 (< 0.05) # | ↑Hk2 |
Arginine and proline metabolism | ↓ ‒1.4 (0.21) | ↓Arg1, ↓P4ha1 | → | ↑P4ha3 | ↑ 1.3 (0.22) | ‒ |
Citrate cycle (TCA cycle) | ↑ 1.8 (0.06) | ‒ | ↑ 1.5 (0.09) | ‒ | → | ‒ |
Glycolysis / Gluconeogenesis | → | ↓Pgk1 | ↑ 1.3 (0.20) | ‒ | ↑ 2.1 (< 0.05) # | ↑Aldoc, ↑Hk2 |
Transcriptional misregulation in cancer | → | ↑Ccnd2, ↑Tgfbr2, ↑Spint1 | ↑ 1.6 (0.06) | ↑Ngfr, ↑Etv4, ↑Baiap3, ↑Runx1, *↑Tgfbr2, *↑Ccnd2 | ↓ ‒1.3 (0.21) | ↓Igf1 |
Pathways in cancer | ↑ 1.6 (0.09) | ↑Cxcl12, ↑Mmp2, ↑Ccnd2, ↑Gli1, ↑Tgfbr2 | ↑ 1.7 (< 0.05) | *↑Mmp2, *↑Cxcl12, ↑Tcf7, ↑Hhip, ↑Jag2, ↑Axin2, ↑Runx1, ↑Lama5, *↑Tgfbr2, *↑Ccnd2, et seq. | → | ↓Rac2, ↓Igf1 |
Apoptosis | → | ↑Ptpn13 | ↑ 1.3 (0.22) | ↑Ngfr, *↑Ptpn13 | ↓ ‒1.6 (0.09) | ↓Ctsh |
Focal adhesion | ↑ 1.6 (0.09) | ↑Tnxb, ↑Vwf, ↑Ccnd2, ↑Flnc | ↑ 1.8 (< 0.05) | ↑Tnc, ↑Flnc, ↑Col1a2, ↑Col1a1, ↑Col6a2, ↑Lama5, *↑Ccnd2, ↑Thbs2, ↑Col6a1 | ↓ ‒1.3 (0.22) | ↓Spp1, ↓Rac2, ↓Igf1 |
HIF-1 signaling pathway | ↓ ‒1.8 (< 0.05) | ↓Pgk1, ↓Pdk1, ↓Egln3, ↓Slc2a1 | → | *↓Egln3 | ↑ 1.5 (0.10) | ↑Hk2 |
mTOR signaling pathway | ↓ ‒1.4 (0.15) | ↓Rragd | → | ‒ | ↑ 1.6 (0.07) | ‒ |
Notch signaling pathway | ↑ 1.5 (0.13) | ‒ | ↑ 1.7 (< 0.05) | ↑Jag2 | → | ‒ |
PPAR signaling pathway | ↑ 2.0 (< 0.05) | ↑Plin4, ↑Fabp4, ↑Scd1 | ↑ 1.5 (0.07) | *↑Scd1 | → | ↓Lpl, ↓Pltp, ↓Cd36 |
TGF-beta signaling pathway | → | ↑Dcn, ↑Tgfbr2, ↑Bambi | ↑ 1.6 (< 0.05) | ↑Nbl1, ↑Id1, ↑Dcn, *↑Tgfbr2, ↑Ltbp1 | → | ‒ |
VEGF signaling pathway | → | ‒ | ↑ 1.4 (0.13) | ‒ | ↓ ‒1.4 (0.17) | ↓Rac2, ↓Mapkapk3 |
Wnt signaling pathway | ↑ 1.7 (0.07) | ↑Sfrp2, ↑Ccnd2, ↑Bambi | ↑ 2.0 (< 0.05) | ↑Tcf7, ↑Serpinf1, ↑Nfatc4, ↑Axin2, *↑Ccnd2 | → | ↓Rac2 |
DNA replication and repair | ||||||
DNA replication | ↑ 1.5 (0.10) | ‒ | → | ‒ | ↓ ‒2.3 (< 0.05) | ‒ |
Fanconi anemia pathway | → | ‒ | ↓ ‒1.5 (0.11) | ↓Polk | ↓ ‒1.5 (0.13) # | ‒ |
Homologous recombination | → | ‒ | ↓ ‒1.4 (0.14) | ‒ | → | ‒ |
mRNA sequencing reported for sub-cohorts (n = 3); threshold for pathway enrichment: fdr < 0.25; thresholds for differentially expressed leading-edge genes: Padj < 0.05, log2 fold change ≥ |1|, SEM ≤ 0.5.
(nes) normalized enrichment score; (fdr) false detection rate; (↑↓) up/down-regulation; (→) no change; * gene response shared with [PRRT]; # pathway response shared with [ET+PRRT].