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. 2022 Dec 16;9:1080964. doi: 10.3389/fmolb.2022.1080964

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Copyright © 2022 Fredericks, East, Shi, Liu, Maschietto, Ayala, Cioffi, Cohen, Fairbrother, Lefort, Nau, Levy, Wang, Batista, Lisi and Monaghan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modeling of the full-length NAb C135 with the full-length N⁰AT1/ACE2/spiker supercomplexes. (A) Two orthogonal views of three NAb C135 (blue, forest, and cyan) and three B⁰AT1/ACE2 (magenta, pink, and grey) dimers bound to one open spike trimer (black for the extended S2 central stalk, and multicolor for NTD and rainbow colors for RBDs). (B) Two NAb C135 bound to the B⁰AT1/ACE2 dimer in the opened ACE2 cleft in four orthogonal views. (C) B⁰AT1/ACE2 dimer with the spike RBD (rainbow color), but without the modeled NAb C135. (D) Two simultaneously modeled NAb C135 on one ACE2 dimer showing steric clashes between the constant domains and heavy/light chains of NAb C135.