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. 2022 Dec 16;10:923525. doi: 10.3389/fpubh.2022.923525

Table 3.

Individual and pooled specificity by serological test method and immunoglobulin class detected.

IgM IgG IgM or IgG
Method and studies TN FP Specificity (95% CI) TN FP Specificity (95% CI) TN FP Specificity (95% CI)
ELISA (n = 94 arms)
A Cramer (2021) 241 9 96.4 (93.3–98.3)
Abdullah Algaissi (2020) 240 10 96.0 (92.8–98.1) 236 14 94.4 (90.8–96.9)
Alexander Krüttgen (2020) 24 1 96.0 (79.6–99.9)
Angel Guevara (2021) 49 0 100 (92.7–100)
Anita S. Iyer (2020) 1,548 0 100 (99.8–100) 1,548 0 100 (99.8–100)
Antoine-Reid. T (2020) 187 53 77.9 (72.1–83.0)
Archana Thomas (2021) 300 0 100 (98.8–100)
Ariel D. Stock (2020) 79 11 87.8 (79.2–93.7)
Ayesha Appa (2020) 246 15 94.3 (90.7–96.7) 492 30 94.3 (91.9–96.1)
B. Meyer (2020) 316 10 96.9 (94.4–98.5)
Bijon Kumar Sil (2021) 102 3 97.1 (91.9–99.4)
Bin Lou (2020) 300 0 100 (98.8–100) 300 0 100 (98.8–100)
Carleen Klumpp-Thomas (2020) 111 5 95.7 (90.2–98.6)
Caturegli. G (2020) 561 7 98.8 (97.5–99.5)
Chang Zhou (2020) 144 6 96.0 (91.5–98.5) 150 150 50.0 (44.2–55.8)
Christian Wechselberger (2020) 46 13 78.0 (65.3–87.7)
Clarence W Chan (2020) 53 0 100 (93.3–100) 57 0 100 (93.7–100)
D. S. Y. Ong (2020) 114 2 98.3 (93.9–99.8)
Daniel Brigger (2020) 1,650 105 94.0 (92.8–95.1)
David M (2020) 172 16 91.5 (86.5–95.1) 188 0 100 (98.1–100)
E. Catry (2020) 100 0 100 (96.4–100)
Ekasit Kowitdamrong (2020) 166 5 97.1 (93.3–99.0)
Eshan U. Patel (2020) 548 14 97.5 (95.9–98.6)
Fei Xiang (2020) 60 0 100 (94.0–100) 57 3 95.0 (86.1–99.0)
Gang Xu (2020) 120 2 98.4 (94.2–99.8)
Giuseppe Vetrugno (2021) 4,290 28 99.4 (99.1–99.6)
Gláucia Cota (2020) 62 54 53.4 (44.0–62.8)
Hadi M. Yassine (2020) 318 32 90.9 (87.3–93.7)
Isabel Montesinos (2020) 71 1 98.6 (92.5–100)
Isabelle Piec (2021) 588 20 96.7 (95.0–98.0)
Iyer. A S (2020) 1,546 2 99.9 (99.5–100) 1,546 2 99.9 (99.5–100)
Jeffrey D. Whitman (2020) 107 1 99.1 (94.9–100)
Jialin Xiang (2020) 37 4 90.2 (76.9–97.3) 39 2 95.1 (83.5–99.4)
Jira Chansaenroj (2021) 130 0 100 (97.2–100)
Joanna Jung (2020) 36 2 94.7 (82.3–99.4)
Julien Favresse (2020) 470 2 99.6 (98.5–99.9)
Julien Marlet (2020) 662 50 93.0 (90.8–94.7)
Justin Manalac (2020) 35 72 32.7 (24.0–42.5)
Katherine Bond (2020) 953 356 72.8 (70.3–75.2)
Kristin E. Mullins (2021) 440 1 99.8 (98.7–100)
Lene H. Harritsh (2021) 979 6 99.4 (98.7–99.8) 1,182 14 98.8 (98.0–99.4) 1,273 6 99.5 (99.0–99.8)
Luciano F. Huergo (2021) 1,019 9 99.1 (98.3–99.6)
Marc Kovac (2020) 82 34 70.7 (61.5–78.8)
Margherita Bruni (2020) 414 22 95.0 (92.5–96.8)
Maria Martínez Serrano (2020) 84 0 100 (95.7–100)
Marie Tré-Hardy (2020) 79 0 100 (95.4–100) 79 2 97.5 (91.4–99.7)
Marzia Nuccetelli (2020) 82 6 93.2 (85.7–97.5)
Marzia Nuccetelli (2021) 118 0 100 (96.9–100)
Massimo Pieri (2020) 40 0 100 (91.2–100) 80 0 100 (95.5–100)
Maximilian Kittel (2020) 91 6 93.8 (87.0–97.7)
Melkon G. DomBourian (2020) 106 0 100 (96.6–100)
N. Davidson (2020) 55 7 259 17 93.8 (90.3–96.4)
Qiang Wang (2020) 50 22 69.4 (57.5–79.8)
Reuben McGregor (2020) 195 0 100 (98.1–100) 195 0 100 (98.1–100) 113 0 100 (96.8–100)
Sarah E. Turbett (2020) 1,259 9 99.3 (98.7–99.7)
Sarah M Hicks (2020) 182 2 98.9 (96.1–99.9)
Stefani N. Thomas (2021) 237 0 100 (98.5–100)
Suliman A Alharbi (2020) 63 2 96.9 (89.3–99.6) 1 4 20.0 (0.5–71.6)
Tania ReginaTozetto-Mendoza (2021) 92 2 97.9 (92.5–99.7)
Teodora Djukic (2021) 66 2 97.1 (89.8–99.6) 67 1 98.5 (92.1–100)
Teresa Stock da Cunha (2020) 150 2 98.7 (95.3–99.8) 149 3 98.0 (94.3–99.6)
Thamir A. Alandijany (2020) 304 5 98.4 (96.3–99.5)
Thomas Nicol (2020) 147 5 96.7 (92.5–98.9)
Thomas W. McDade (2020) 13 2 86.7 (59.5–98.3)
Traugott M (2020) 97 3 97.0 (91.5–99.4) 98 2 98.0 (93.0–99.8) 97 3 97.0 (91.5–99.4)
Victoria Indenbaum (2020) 180 0 100 (98.0–100) 318 6 98.1 (96.0–99.3)
Wanbing Liu (2020) 100 0 100 (96.4–100) 100 0 100 (96.4–100) 100 0 100 (96.4–100)
Zahra Rikhtegaran Tehrani (2020) 870 15 98.3 (97.2–99.0) 591 9 98.5 (97.2–99.3)
Brad Poore (2021) 129 0 100.0 (97.0–100.0)
Valentina Pecoraro (2021) 2 13 13.0 (2.0–40.0) 2 13 13.0 (2.0–40.0)
James Nyagwange (2021) 515 1 100.0 (99.0–100.0) 507 9 98.0 (97.0–99.0)
Pan-pan Liu (2021) 90 0 100 (96.0–100) 90 0 100.0 (96.0–100.0) 90 0 100.0 (96.0–100.0)
Maryam Ranjbar (2021) 109 3 97.0 (92.0–99.0) 110 2 98.0 (94.0–100.0)
Marina Bubonja-Šonje (2021) 100 0 100 (96.0–100) 99 1 99.0 (95.0–100.0)
Tom Lutalo (2021) 90 10 90.0 (82.0–95.0) 98 2 98.0 (93.0–100.0) 89 11 89.0 (81.0–94.0)
Oskar Ekelund (2021) 148 2 99.0 (95.0–100.0)
P. J. Ducrest (2021) 95 3 97.0 (91.0–99.0)
Norihito Kaku (2021) 174 0 100.0 (98.0–100.0)
David Triest (2021) 84 5 94.0 (87.0–98.0)
Maemu P. Gededzha (2021) 132 7 95.0 (90.0–98.0)
Robert Needle (2021) 109 2 98.0 (94.0–100.0)
Arwa A. Faizo (2021) 91 1 99.0 (94.0–100.0)
Rosa Camacho-Sandoval (2021) 224 5 98.0 (95.0–99.0)
Theano Lagousi (2021) 137 13 91.0 (86.0–95.0) 146 4 97.0 (93.0–99.0)
Adnan Alatoom (2021) 30 0 100.0 (88.0–100.0)
Fehintola Ige (2021) 99 0 100.0 (96.0–100.0)
Ingrid Sander (2022) 176 7 96.0 (92.0–98.0)
Shiji Wu (2022) 139 3 98.0 (94.0–100.0) 138 4 97.0 (93.0–99.0)
Vijayalakshmi Nandakumar (2021) 184 8 96.0 (92.0–98.0)
Elena Riester (2021) 9,561 14 100.0 (100.0–100.0)
Ismar A. Rivera-Olivero (2022) 40 0 100.0 (91.0–100.0)
Nina Lagerqvist (2021) 95 1 99.0 (94.0 to100.0)
Ji Luo (2022) 1,489 1 100.0 (100.0–100.0)
Suellen Nicholson (2021) 179 30 86.0 (80.0–90.0)
Pooled 7,712 138 98.0 (98.0–99.0) 26,510 1,219 96.0 (95.0–96.0) 15,059 159 99.0 (99.0–99.0)
LFIA (n = 55 arms)
A Cramer (2021) 20 0 100 (93.2–100)
Chao Huang (2020) 13 1 92.9 (66.1–99.8)
Choe JY (2020) 67 12 84.8 (75.0 to91.9)
Clarence W (2021) 165 3 98.2 (94.9–99.6)
D. S. Y. Ong (2020) 126 3 97.7 (93.4–99.5)
Diego O. Andrey (2020) 44 1 97.8 (88.2–99.9)
E Tuaillon (2020) 19 1 95.0 (75.1–99.9) 20 0 100 (83.2–100)
E. Catry (2020) 288 12 96.0 (93.1–97.9) 396 4 99.0 (97.5–99.7) 200 0 100 (98.2–100)
Feng M (2020) 72 5 93.5 (85.5–97.9) 77 0 100 (95.3–100)
Francis Stieber (2020) 75 0 100 (95.2–100)
Francisco Javier Candel González (2020) 5 0 100 (47.8–100)
Giovanni Sotgiu (2020) 1 21 45.0 (1.0–22.8) 16 6 72.7 (49.8–89.3)
Giuseppe Vetrugno (2021) 4,173 145 96.6 (96.1–97.2)
Gladys VirginiaGuedez-López (2020) 76 19 80.0 (70.5–87.5) 80 15 84.2 (75.3–90.9) 34 26 56.7 (43.2–69.4)
Gláucia Cota (2020) 668 28 96.0 (94.2–97.3)
Hua Li (2020) 136 3 97.8 (93.8–99.6) 138 1 99.3 (96.1–100) 135 4 97.1 (92.8–99.2)
Isabel Montesinos (2020) 213 3 98.6 (96.0–99.7) 213 3 98.6 (96.0–99.7)
J. Van Elslande (2020) 94 9 91.3 (84.1–95.9) 101 2 98.1 (93.2–99.8) 93 10 90.3 (82.9–95.2)
Jeffrey D. Whitman (2020) 900 56 94.1 (92.5–95.5) 933 23 97.6 (96.4–98.5) 1,000 0 100 (99.6–100)
Kathrine McAulay (2020) 416 4 99.0 (97.6–99.7)
Klaus Puschel (2021) 215 3 98.6 (96–99.7)
Laurent Dortet (2020) 150 0 100 (97.6–100)
Linda Hueston (2020) 2,621 8 99.7 (99.4–99.9) 2,607 22 99.2 (98.7–99.5) 2,626 2 99.9 (99.7–100)
Lixia Zhang (2020) 20 0 100 (83.2–100) 20 0 100 (83.2–100)
Maria Martínez Serrano (2020) 79 5 94.0 (86.7–98.0) 83 1 98.8 (93.5–100)
Marta Cancella de Abreu (2020) 16 4 80.0 (6.3–94.3)
Maya Moshe (2021) 500 0 100 (99.3–100) 250 0 100 (98.5–100)
Morihito Takita (2020) 38 2 95.0 (83.1–99.4)
Niko Kohmer (2020) 19 0 100 (82.4–100)
Peter Findeisen (2020) 89 3 96.7 (90.8–99.3)
Qiang Wang (2020) 50 22 69.4 (57.5–79.8)
ROSELLE S. ROBOSA (2020) 71 0 100 (94.9–100) 70 1 98.6 (92.4–100) 70 1 98.6 (92.4–100)
Scott J C Pallett (2020) 286 16 94.7 (91.5–96.9)
Shun Kaneko (2020) 100 0 100 (96.4–100) 100 0 100 (96.4–100)
Silvia Montolio Breva (2021) 59 2 96.7 (88.7–99.6)
Thomas Nicol (2020) 145 7 95.4 (90.7–98.1) 147 5 96.7 (92.5–98.9)
Tian Wen (2020) 30 0 100 (88.4–100)
Vani Maya (2021) 25 0 100 (86.3–100)
Won Lee (2020) 47 3 94.0 (83.5–98.7) 49 1 98.0 (89.4–99.9)
Yaqing Li (2020) 291 9 97.0 (94.4–98.6)
Yunbao Pan (2020) 8 14 36.4 (17.2–59.3) 13 9 59.1 (36.4–79.3) 14 8 63.6 (40.7–82.8)
Zahra Rikhtegaran Tehrani (2020) 275 25 91.7 (87.9–94.5) 280 20 93.3 (89.9–95.9) 100.0 (48.0–100.0)
Ziad Daoud (2020) 363 2 99.5 (98.0–99.9) 365 0 100 (99.0–100) 97.0 (94.0–99.0)
Jialin Xiang ((2020)/10) 13 4 76.5 (50.1–93.2)
Valentina Pecoraro (2021) 3 12 20.0 (4.0–48.0) 3 12 20.0 (4.0–48.0)
Marina Bubonja-Šonje (2021) 100 0 100.0 (96.0–100.0) 100 0 100.0 (96.0–100.0)
Bianca A. Trombetta (2021) 55 1 98.0 (90.0–100.0) 56 0 100.0 (94.0–100.0) 56 0 100.0 (94.0–100.0)
Oskar Ekelund (2021) 145 5 97.0 (92.0–99.0)
Norihito Kaku (2021) 174 0 100.0 (98.0–100.0) 172 2 99.0 (96.0–100.0)
Sérgio M. de Almeida (2021) 37 0 100.0 (91.0–100.0) 37 0 100.0 (91.0–100.0) 37 0 100.0 (91.0–100.0)
Amedeo De Nicolò (2021) 75 4 95.0 (88.0–99.0)
Dennis Souverein (2021) 218 1 100.0 (97.0–100.0) 218 1 100.0 (97.0–100.0) 218 1 100.0 (97.0–100.0)
Sophie I. Owen (2021) 86 19 82.0 (73.0–89.0) 97 98 50.0 (43.0–57.0) 85 20 81.0 (72.0–88.0)
Shiji Wu (2022) 142 0 100.0 (97.0–100.0) 142 0 100.0 (97.0–100.0)
Ismar A. Rivera-Olivero (2022) 37 3 93.0 (80.0–98.0) 40 0 100.0 (91.0–100.0)
Pooled 5,604 256 96.0 (96.0–97.0) 6,947 225 97.0 (96.0–97.0) 12,141 317 97.0 (97.0–98.0)
CLIA (n = 64 arms)
Bin Lou (2020) 298 2 99.3 (97.6–99.9) 299 1 99.7 (98.2–100)
Dachuan Lin (2020) 74 6 92.5 (84.4–97.2) 78 2 97.5 (91.3–99.7)
Wanbing Liu (2020) 268 2 99.3 (97.4–99.9) 81 0 100 (95.5–100)
Maria Infantino (2020) 59 5 92.2 (82.7–97.4) 64 0 100 (94.4–100)
Shao Lijia (2020) 50 0 100 (92.9–100) 50 0 100 (92.9–100)
Fang Hu (2020) 109 1 99.1 (95.0–100) 106 4 96.4 (91.0–99.0) 134 0 100 (97.3–100)
Charpentier, C (2020) 50 2 96.2 (86.8–99.5)
Jääskeläinen, A J (2020) 77 4 95.1 (87.8–98.6)
Ping li (2020) 126 8 94 (88.6–97.4) 133 1 99.3 (95.9–100)
Chew, K L (2020) 163 0 100 (97.8–100)
Fabrizio Bonelli (2020) 4,923 117 97.7 (97.2–98.1)
Narjis Boukli (2020) 297 3 99 (97.1–99.8)
Andrew Bryan (2020) 1,010 10 99 (98.2–99.5)
MarinaJohnson (2020) 189 5 97.4 (94.1–99.2)
Niko Kohmer (2020) 35 0 100 (90.0–100)
Z. Huang (2020) 190 4 97.9 (94.8–99.4)
Ayesha Appa (2020) 1,874 6 99.7 (99.3–99.9)
Chungen Qian (2020) 946 26 97.3 (96.1–98.2) 947 25 97.4 (96.2–98.3) 72 0 100 (95.0–100)
Marie Tré-Hardy (2020) 4 0 100 (39.8–100)
Isabel Montesinos (2020) 72 0 100 (95.0–100) 72 0 100 (95.0–100)
Julien Marlet (2020) 176 2 98.9 (96.0–99.9)
Elitza S. Theel (2020) 297 1 99.7 (98.1–100)
Massimo Pieri (2020) 40 0 100 (91.2–100) 40 0 100 (91.2–100) 374 15 96.1 (93.7–97.8)
Thomas Nicol (2020) 151 1 99.3 (96.4–100)
Morihito Takita (2020) 38 2 95 (83.1–99.4)
Raymond T (2020) 234 1 99.6 (97.7–100) 233 2 99.1 (97.0–99.9) 355 35 91 (87.7–93.7)
Justin Manalac (2020) 1,236 25 98 (97.1–98.7) 55 6 90.2 (79.8–96.3)
C. S. Lau (2020) 978 2 99.8 (99.3–100)
Yafang Wan (2020) 371 19 95.1 (92.5–97.0) 355 35 91 (87.7–93.7) 129 1 99.2 (95.8–100)
E. Catry (2020) 98 2 98 (93–99.8) 100 0 100 (96.4–100)
Li-xiang Wu (2020) 229 5 97.9 (95.1–99.3) 219 15 93.6 (89.6–96.4) 215 19 91.9 (87.6–95.0)
Jenna Rychert (2020) 99 1 99 (94.6–100)
Anja Dörschug (2020) 189 3 98.4 (95.5–99.7)
Nan wu (2020) 34 0 100 (89.7–100) 32 2 94.1 (80.3–99.3)
Shey-Ying Chen (2020) 190 4 97.9 (94.8–99.4)
Xueping Qiu (2020) 377 12 96.9 (94.7–98.4) 377 12 96.9 (94.7–98.4) 374 15 96.1 (93.7–97.8)
Hélène Haguet (2021) 75 1 98.7 (92.9–100) 76 0 100 (95.3–100)
Huihui Wang (2021) 94 94 50 (42.6–57.4)
Rasmus Strand MSc (2021) 45 5 90 (78.2–96.7) 49 1 98 (89.4–99.9)
Tania ReginaTozetto-Mendoza (2021) 92 2 97.9 (92.5–99.7)
C. S. Lau (2021) 245 3 98.8 (96.5–99.7)
Luigi Vimercati (2021) 2,117 272 88.6 (87.3–89.9) 2,341 48 98 (97.3–98.7)
Sousuke Kubo (2021) 1,000 0 100 (99.6–100) 1,000 0 100 (99.6–100)
Anna Schaffner (2020) 1,157 2 99.8 (99.4–100)
N. Davidson (2020) 130 8 94.2 (88.9–97.5)
A Cramer (2021) 25 0 100 (86.3–100)
Victoria Higgins (2021) 107 0 100 (96.6–100) 214 0 100 (98.3–100) 107 0 100 (96.6–100)
Myriam C. Weber (2020) 2,377 9 99.6 (99.3–99.8) 1,192 1 99.9 (99.5–100)
Maximilian Kittel (2020) 188 6 96.9 (93.4–98.9) 288 3 99 (97.0–99.8) 42 0 100 (91.6–100)
Christian Irsara (2021) 487 2 99.6 (98.5–100) 627 2 99.7 (98.9–100)
Yaqing Li (2020) 204 10 95.3 (91.6–97.7)
Yuki Nakano (2021) 125 19 86.8 (80.2–91.9) 144 0 100 (97.5–100)
Brad Poore (2021) 129 0 100.0 (97.0–100.0)
Valentina Pecoraro (2021) 2 13 13.0 (2.0–40.0) 2 13 13.0 (2.0–40.0)
Gabriel N Maine (2022) 302 3 99.0 (97.0–100.0)
Kotaro Aoki (2021) 677 7 99.0 (98.0–100.0)
Marina Bubonja-Šonje (2021) 99 1 99.0 (95.0–100.0)
Oskar Ekelund (2021) 149 1 99.0 (96.0–100.0)
Lau CS (2021) 248 0 100.0 (99.0–100.0)
Maria del Mar Castro (2021) 59 0 100.0 (94.0–100.0)
Robert Needle (2021) 109 2 98.0 (94.0–100.0)
Adnan Alatoom (2021) 30 0 100.0 (88.0–100.0)
Shiji Wu (2022) 142 0 100.0 (97.0–100.0) 142 0 100.0 (97.0–100.0)
Vijayalakshmi Nandakumar (2021) 189 3 98.0 (96.0–100.0)
Pooled 6,336 403 94.0 (93.0–95.0) 23,686 384 98.0 (98.0–99.0) 7,250 215 97.0 (97.0–97.0)

Ig, immunoglobulin; TP, true positive; FN, false negative; TN, true negative; FP, false positive; ELISA, enzyme linked immunosorbent assay; LFIA, lateral flow immunoassay; CLIA, chemiluminescent immunoassay.