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The role of PPARα in Alzheimer’s disease. PPARα is involved in Alzheimer’s disease with diverse mechanisms. Activation of PPARα promotes lipid oxidation and ketogenesis through mitochondrial biogenesis. PPARα activation also leads to Aβ clearance by App repression and autophagy of neurons. Neuroprotective factors like BDNF might also be activated by PPARα agonists for AD treatment.
