Figure 2.

Dimension reduction for the visualization of high-order drug combinations

In this example, the two-dimensional coordinates of each three-drug dose combination are determined by multi-dimensional scaling based on the similarity of their dose ranges, after which the synergy scores and sensitivity scores can be visualized on the map. Each dot in the map is annotated with its associated dose rankings for the three drugs $(r_1;r_2;r_3)$. For example, a dot with a label 4;1;2 shows a combination involves the 4th dose of drug 1, the 1st dose of drug 2, and the 2nd dose of drug 3.