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. 2022 Jan 25;20(3):587–596. doi: 10.1016/j.gpb.2022.01.004

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Example of surface plots for higher-order drug combinations

A. The dose–response map for a synergistic drug combination (pyronaridine tetraphosphate–piperaquine–darunavir ethanolate, left panel) compared to an antagonistic drug combination (pyronaridine tetraphosphate–piperaquine–lopinavir, right panel). B. The ZIP synergy score map for the same drug combinations. For surface plots of other synergy scores, including HSA, BLISS, and LOEWE, see Figure S2. HSA, highest single agent; BLISS, Bliss independence; LOEWE, Loewe additivity; ZIP, zero interaction potency.