Table 2.
The regulation of circRNA/miRNA/target protein network in chronic myeloid leukemia (CML)
| CircRNAs | MiRNAs | Target proteins | Functions |
|---|---|---|---|
| circ_0080145 | miR‐29b | / | Regulates CML cell proliferation |
| circ_0009910 | miR‐34a‐5p | ULK1 | Accelerates imatinib‐resistance in CML cells by modulating autophagy |
| circ_0080145 | miR‐203 | ABL1 | Responsible for the development of imatinib chemoresistance in CML |
| circ 0051886 | miR‐637 | ABL1 | Responsible for the development of imatinib chemoresistance in CML |
| circ_0058493 | miR‐548b‐3p | / | As a novel biomarker for Imatinib‐resistant CML |
| F‐circBA1 | miR‐148‐3p | CDC25B | Displays an oncogenic role in CML cells |
| circ_0080145 | miR‐326 | PPFIA1 | Enhances imatinib resistance in CML |
Abbreviations: ABL1, abelson 1; CDC25B, cell cycle division 25B; circRNAs, circular RNAs; miRNAs, micro RNAs; PPFIA1, liprin‐alpha1; ULK1, UNC‐51‐like kinase 1.