Table 1.

Interface metrics as determined by the Rosetta InterfaceAnalyzer. ΔΔG is measured in Rosetta Energy Units (REU).

Parameter		Design model	Experimental model
ΔΔG (REU)	2-fold	−30.445	−36.724
	3-fold	−64.241	−76.519
No. of interface residues	2-fold	52	56
	3-fold	113	112
ΔSASA_total (Å2)	2-fold	1337.885	1312.648
	3-fold	2420.977	2484.479
ΔSASA_hydrophobic (Å2)	2-fold	1067.291	1097.332
	3-fold	1756.790	1730.666
Shape complementarity	2-fold	0.508	0.531
	3-fold	0.733	0.698