Response assessment of target lesions. To characterize the effects of avelumab alone and in combination with RT, only one lesion was irradiated per patient. Subsequently, both irradiated and nonirradiated lesions were monitored. (A) Response of irradiated lesion. (B) Response of nonirradiated lesion. Coloration denotes CR, PR, SD, and PD as indicated in the figure legends. CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; RT, radiation therapy.