Table 7.

General principles for the treatment of irAEs

Treatment	Grade
	G1 (hospitalization not required)	G2 (hospitalization not required)	G3 (hospitalization required)	G4 (hospitalization required, considering the ICU)
Glucocorticoids	Not recommended	Local use of glucocorticoids or systemic use of glucocorticoids, with oral administration of prednisone at 0.5–1 mg/ (kg·day)	Systemic therapy with glucocorticoids, oral administration of prednisone, or intravenous administration of methylprednisolone at 1–2 mg/(kg·day)	Systemic therapy with glucocorticoids, intravenous administration of methylprednisolone at 1–2 mg/(kg·day). For 3 consecutive days, if the symptoms are relieved, gradually reduce the dose to 1 mg/(kg·day) for maintenance, and then gradually reduce the dose until discontinuing the drug about 6 weeks later
Other immunosuppressive agents	Not recommended	Not recommended	For patients whose symptoms are not relieved after 3–5 days of glucocorticoid treatment, consider using it under the guidance of a specialist	For patients whose symptoms are not relieved after 3–5 days of glucocorticoid treatment, consider treatment under the guidance of a specialist
ICI treatment	Continue the treatment	Suspend the treatment	Discontinue and discuss whether to resume ICI treatment based on the patient's risk/benefit ratio	Permanent withdrawal

ICU, intensive care unit.