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. 2022 Dec 15;67:101659. doi: 10.1016/j.molmet.2022.101659

Figure 5.

Figure 5

Effect of SCD1 knockout in mouse on pancreatic islet cytoarchitecture. (A) Immunofluorescent labeling of insulin-positive cells (red) and glucagon-positive cells (green) in pancreatic islets in WT and SCD1−/− mice that were fed a chow or HF diet, showing the distribution of these cells within islets. The arrows indicate the following: white (α-cells located in the core of the islet), blue (irregular-shaped islet), yellow (disproportionate number of α-cells relative to β-cells within the islet). Images are representative of at least three mice. Scale bars = 20 μm. (B–D) Morphometric analyses of pancreatic islets in sections of the pancreas from WT and SCD1−/− mice that were fed a chow or HF diet: β-cell area (B), α-cell area (C), and α- to β-cell ratio (D). The data are expressed as mean ± SD. n = 3 mice/group. ∗p < 0.05, ∗∗p < 0.005, vs. WT chow; #p < 0.05, vs. WT HF.