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. 2022 Dec 14;9(12):ofac641. doi: 10.1093/ofid/ofac641

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© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Phases for the Veterans Affairs (VA) Science and Health Initiative to Combat Infectious and Emerging Life-threatening Diseases (SHIELD) development and phase 1 biological sample and application processing. A, Developmental plans for VA SHIELD. The phase 1 VA Sweep protocol is underway to assemble remnant samples from severe acute respiratory syndrome coronavirus 2–affected Veterans and controls (see below). Phase 2 will be implemented in 2023 with the VA SHIELD “Umbrella” amendment to collect prospective samples from Veterans based on criteria that are being finalized. Phase 3 prepares the system for the next emerging disease that warrants a VA SHIELD response, which is underway and will become more effective upon implementation of phase 2. B, VA SHIELD sample flow and application approval under phase 1, the VA Sweep protocol. The steps following biological samples and data into VA SHIELD (left side) and following the development of an application for biological samples and the provision of samples to an approved project (right side) are presented. Abbreviations: CDW, Corporate Data Warehouse; COVID-19, coronavirus disease 2019; LIMS, laboratory information management system; MVP, Million Veteran Program; PI, principal investigator; PSRB, Programmatic and Scientific Review Board; SHIELD, Science and Health Initiative to Combat Infectious and Emerging Life-threatening Diseases; VA, Veterans Affairs.