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. 2022 Nov 2;11(12):1232–1244. doi: 10.1093/stcltm/szac076

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Improvement of muscle contraction in aganglionic colon by transplantation of HSCR-SCs. (A) Representative traces of colonic contractile force in Wnt1::Cre^-;R26-iDTR that receives DT injection (A, Cre- + DT, blue line), Wnt1::Cre⁺;R26-iDTR (Cre+) with DT injection (A, Cre+ + DT, red line) and Cre+ + DT followed by HSCR-SCs transplantation (A, Cre+ + DT + Cells, green line). Voltage-dependent changes in contractile force of colonic muscle preparation after EFS (30 V, 0.3 ms 5H z for 30 s) showed cell transplantation significantly improved muscle contractile activity (B, n = 4, ***P < .001, **P < .01) This response was significantly reduced by the presence TTX. (Bʹ, n = 4, * P < .05). Data are represented as mean ± SD from 4 mice per group by Student’s t-test. Abbreviations: TTX, tetrodotoxin; EFS, electrical field stimulation.