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. 2022 Dec 30;7:174. doi: 10.1038/s41541-022-00586-7

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The dot plots show accumulated data from array-based measurement of 6693 samples. Each dot in the scatter plots correspond to a different sample. Bead-based arrays were incubated with 6693 sera diluted 1:1000 for 1 h prior to labeling with R-Phycoerythrin-conjugated anti-Human IgG. a–f The x-axes show median fluorescence intensity (MFI) of anti-human IgG binding to beads coupled with RBDwt divided by MFI measured for beads with no virus protein (relative MFI, rMFI). The y-axes show anti-human IgG rMFI measured for beads coupled with RBDs from indicated variants. g–l The y-axes are the same as in dot plots (a–f), while the x-axis shows rMFI for antibodies binding to beads coupled with nucleocapsid from SARS-CoV-2wt. Green dots: post-vaccine sera, red dots: sera obtained in 2020 from SARS-CoV-2 convalescents. Blue dots: sera obtained 10–20 days after symptom debut of Omicron BA.1 infection in double-vaccinated healthy individuals. Source data are provided as a Source Data file.