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. 2022 Dec 14;8(12):1695–1703. doi: 10.1021/acscentsci.2c00998

Figure 3.

Figure 3

Nb 2D9 and 2D9_W108L fused with Fc or Trim21 induced the degradation of BCL11A but not BCL11B. (A) Degradation of BCL11A upon lentiviral transduction of Nb-Fc fusion in differentiated HUDEP-2 cells. (B) Lentiviral transduction of Nb-wtTrim21 but not Nb-mutTrim21 led to degradation of BCL11A in HUDEP-2 cells. (C) Nb-wtTrim21 but not Nb-mutTrim21 led to degradation of overexpressed BCL11A in HEK293T cells. (D) Neither Nb-Fc nor Nb-Trim21 mediated degradation of overexpressed BCL11B in HEK293T cells.