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. 2022 Jun 1;206(8):961–972. doi: 10.1164/rccm.202107-1774OC

Figure 1.

Figure 1.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human lung microvascular endothelial cell (HMVEC) infection and endothelial permeability. (A) SARS-CoV-2 mRNA was detected and quantified in HMVEC lysates after 24 and 72 hours of exposure to live SARS-CoV-2 virus (multiplicity of infection [MOI] of 1; orange, strain nCoV/USA-WA1/2020) using quantitative PCR (TaqMan 2019-nCoV assay). This example shows cells from a single donor; dots are biological replicates. (B1–B6) Transendothelial resistance during treatment with medium (black line) or live virus (MOI of 1; orange) in six HMVEC donors. (B7) The corresponding area under the curve (AUC) for HMVECs on each of the six donors. *P < 0.05, **P < 0.01, ***P < 0.001 by two-tailed Mann-Whitney U test.