Age >37 years at inclusion |
1.09 |
0.21–6.00 |
1 |
|
|
|
Sex—male |
0.65 |
0.12–3.61 |
0.709 |
|
|
|
Disease duration, >9 years |
0.11 |
0.01–0.69 |
0.008 |
|
|
|
Disease location |
|
|
|
|
|
|
Ileum |
2.42 |
0.27–22.3 |
0.363 |
|
|
|
Ileocolonic |
0.54 |
0.09–3.03 |
0.459 |
|
|
|
Colon |
1.05 |
0.08–9.08 |
1 |
|
|
|
Disease behavior |
|
|
|
|
|
|
Inflammatory disease |
5.23 |
0.76–44.4 |
0.079 |
|
|
|
Stricturing disease |
0.42 |
0.06–2.36 |
0.295 |
|
|
|
Penetrating disease |
0.59 |
0.08–3.40 |
0.705 |
|
|
|
Perianal disease |
1.58 |
0.30–9.54 |
0.715 |
|
|
|
Anal fistula |
0.59 |
0.08–3.40 |
0.705 |
|
|
|
Prior intestinal resections |
0.21 |
0.03–1.19 |
0.066 |
|
|
|
Prior biologics |
|
|
|
|
|
|
Naive to anti-TNF agents |
7.67 |
0.53–450.7 |
0.089 |
|
|
|
2 anti-TNF agents |
0.18 |
0.02–1.15 |
0.064 |
|
|
|
Disease activity |
|
|
|
|
|
|
CDAI score >340 at baseline |
0.52 |
0.04–3.59 |
0.682 |
|
|
|
CRP >0.5mg/dL at baseline |
2.82 |
0.50–20.8 |
0.271 |
|
|
|
Albumin ≥3.8mg/dL at baseline |
2.63 |
0.38–18.7 |
0.388 |
|
|
|
SES-CD score >10 at baseline |
0.53 |
0.06–4.21 |
0.659 |
|
|
|
70-point response at week 8 |
10.4 |
1.51–127.4 |
0.007 |
|
|
|
Clinical remission at week 8 |
21.0 |
2.57–202.4 |
<0.001 |
24.5 |
3.37–178.0 |
0.002 |
CRP >0.5mg/dL at week 8 |
0.29 |
0.04–1.67 |
0.141 |
|
|
|
Albumin ≥3.8mg/dL at week 8 |
13.0 |
1.83–163.7 |
0.005 |
|
|
|
Concomitant medication |
|
|
|
|
|
|
5-aminosalicylic acid |
0.94 |
0.17–5.74 |
1 |
|
|
|
Enteral nutrition (≥900 kcal/day) |
0.89 |
0.15–4.84 |
1 |
|
|
|
Corticosteroids or budesonide |
1.83 |
0.35–10.2 |
0.475 |
|
|
|
Immunosuppressants |
0.53 |
0.09–2.82 |
0.477 |
|
|
|