TABLE 2.
Univariate and Multivariate Predictors for Clinical Remission at Week 52
| Univariate Analyses | Multivariate Analyses | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |
| Age >37 years at inclusion | 1.09 | 0.21–6.00 | 1 | |||
| Sex—male | 0.65 | 0.12–3.61 | 0.709 | |||
| Disease duration, >9 years | 0.11 | 0.01–0.69 | 0.008 | |||
| Disease location | ||||||
| Ileum | 2.42 | 0.27–22.3 | 0.363 | |||
| Ileocolonic | 0.54 | 0.09–3.03 | 0.459 | |||
| Colon | 1.05 | 0.08–9.08 | 1 | |||
| Disease behavior | ||||||
| Inflammatory disease | 5.23 | 0.76–44.4 | 0.079 | |||
| Stricturing disease | 0.42 | 0.06–2.36 | 0.295 | |||
| Penetrating disease | 0.59 | 0.08–3.40 | 0.705 | |||
| Perianal disease | 1.58 | 0.30–9.54 | 0.715 | |||
| Anal fistula | 0.59 | 0.08–3.40 | 0.705 | |||
| Prior intestinal resections | 0.21 | 0.03–1.19 | 0.066 | |||
| Prior biologics | ||||||
| Naive to anti-TNF agents | 7.67 | 0.53–450.7 | 0.089 | |||
| 2 anti-TNF agents | 0.18 | 0.02–1.15 | 0.064 | |||
| Disease activity | ||||||
| CDAI score >340 at baseline | 0.52 | 0.04–3.59 | 0.682 | |||
| CRP >0.5mg/dL at baseline | 2.82 | 0.50–20.8 | 0.271 | |||
| Albumin ≥3.8mg/dL at baseline | 2.63 | 0.38–18.7 | 0.388 | |||
| SES-CD score >10 at baseline | 0.53 | 0.06–4.21 | 0.659 | |||
| 70-point response at week 8 | 10.4 | 1.51–127.4 | 0.007 | |||
| Clinical remission at week 8 | 21.0 | 2.57–202.4 | <0.001 | 24.5 | 3.37–178.0 | 0.002 |
| CRP >0.5mg/dL at week 8 | 0.29 | 0.04–1.67 | 0.141 | |||
| Albumin ≥3.8mg/dL at week 8 | 13.0 | 1.83–163.7 | 0.005 | |||
| Concomitant medication | ||||||
| 5-aminosalicylic acid | 0.94 | 0.17–5.74 | 1 | |||
| Enteral nutrition (≥900 kcal/day) | 0.89 | 0.15–4.84 | 1 | |||
| Corticosteroids or budesonide | 1.83 | 0.35–10.2 | 0.475 | |||
| Immunosuppressants | 0.53 | 0.09–2.82 | 0.477 | |||