Table 3.
Demographics and disease characteristics of patients diagnosed with and treated for moderate-to-severe UC or CD.
| Characteristic | UC (n = 593a) | CD (n = 425a) |
|---|---|---|
| Age, years, mean ± SD | 38.7 ± 12.9 | 37.0 ± 12.7 |
| Male | 376 (63.4) | 232 (54.6) |
| Type of IBD diagnosis | ||
| UC or CD only | 579 (97.6) | 411 (96.7) |
| Both UC and CD | 14 (2.4) | 14 (3.3) |
| IBD-related comorbiditiesb | 322 (54.3) | 238 (56.0) |
| Anemia | 149 (25.1) | 127 (29.9) |
| Anxiety | 118 (19.9) | 85 (20.0) |
| Arthritis (nonpsoriatic, nonrheumatoid) | 10 (1.7) | 10 (2.4) |
| Asthma | 26 (4.4) | 28 (6.6) |
| Cardiovascular disease | 10 (1.7) | 7 (1.6) |
| COPD | 9 (1.5) | 7 (1.6) |
| Depression | 66 (11.1) | 35 (8.2) |
| Diabetes mellitus | 17 (2.9) | 10 (2.4) |
| Hypertension | 51 (8.6) | 22 (5.2) |
| Joint pain | 54 (9.1) | 48 (11.3) |
| Primary sclerosing cholangitis | 8 (1.3) | 3 (0.7) |
| Other | 8 (1.3) | 8 (1.9) |
| None reported | 271 (45.7) | 187 (44.0) |
| Assessment used to classify disease as moderate-to-severec | Mayo Endoscopic score: 435 (73.4) | CDAI: 268 (63.1) |
| Clinical impressiond: 358 (60.4) | HBI: 89 (20.9) | |
| Other: 175 (29.5) | Clinical impressiond: 222 (52.2) | |
| Other: 141 (33.2) | ||
| Assessment score used to classify disease as moderate-to-severe: mean ± SD, n (%)c | Full Mayo score: 8.0 ± 1.5; 420 (70.8) | CDAI: 437.6 ± 153.9; 268 (63.1) |
| Endoscopic subscore: 2.5 ± 0.6; 280 (47.2) | HBI: 23.5 ± 21.0; 89 (20.9) | |
| Rectal bleeding subscore: 2.0 ± 0.7; 259 (43.7) | ||
| Stool frequency subscore: 2.4 ± 0.7; 260 (43.8) | ||
Values are n (%) unless otherwise stated. Abbreviations: CD, Crohn’s disease; CDAI, Crohn’s Disease Activity Index; COPD, chronic obstructive pulmonary disease; HBI, Harvey–Bradshaw Index; IBD, inflammatory bowel disease; UC, ulcerative colitis.
A total of 14 patients were diagnosed with both UC and CD; 6 patients were excluded from the UC analysis as they were treated for their CD diagnosis, and 8 patients were excluded from the CD analysis as they were treated for their UC diagnosis.
During the 6 months prior to diagnosis.
Physicians could use multiple assessments to classify patients with moderate-to-severe UC or CD. Full Mayo Endoscopic Scores range from 0 to 12, with moderate-to-severe UC classified as a Full Mayo Endoscopic Score from 6 to 12. CDAI scores range from 0 to 600 and HBI scores range from 0 to 43, with moderate-to-severe CD classified as CDAI from 220 to 600 or HBI from 6 to 43.
Physicians were provided examples such as “symptoms” and “number of stools” for the option of classification by clinical impression. Common open text responses for clinical impression included: diarrhea, bloody stools, number of stools, abdominal pain, low hemoglobin levels, weight loss, fatigue, rectal pain, loss of appetite, fever, and tenesmus.