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. Author manuscript; available in PMC: 2022 Dec 30.
Published in final edited form as: Ann Intern Med. 2021 Nov 2;175(1):46–55. doi: 10.7326/M21-1436

Appendix Table 4.

Secondary Binary Study Outcomes: Model-Based Proportions and Associated 95% CIs, by Treatment Group and Time Point*

Outcome Usual Care
CBT
Proportion 95% CI
Proportion 95% CI
LB UB LB UB

Benzodiazepine receipt
 Baseline 0.220 0.184 0.255 0.236 0.199 0.273
 3-mo follow-up 0.229 0.195 0.263 0.218 0.185 0.251
 6-mo follow-up 0.226 0.195 0.256 0.206 0.178 0.234
 9-mo follow-up 0.227 0.195 0.258 0.197 0.168 0.227
 12-mo follow-up 0.229 0.193 0.264 0.190 0.157 0.222
Continued long-term opioid therapy
 Baseline 0.767 0.722 0.813 0.763 0.719 0.806
 3-mo follow-up 0.722 0.677 0.767 0.696 0.651 0.740
 6-mo follow-up 0.715 0.672 0.757 0.692 0.650 0.733
 9-mo follow-up 0.700 0.657 0.744 0.681 0.638 0.724
 12-mo follow-up 0.683 0.636 0.729 0.668 0.622 0.713
Average daily dose of opioids ≥90 MME
 Baseline 0.253 0.234 0.273 0.173 0.153 0.192
 3-mo follow-up 0.266 0.252 0.280 0.175 0.160 0.191
 6-mo follow-up 0.256 0.241 0.270 0.162 0.147 0.178
 9-mo follow-up 0.247 0.230 0.265 0.151 0.134 0.168
 12-mo follow-up 0.241 0.218 0.264 0.143 0.122 0.164

CBT = cognitive behavioral therapy; LB = lower bound; MME = morphine milligram equivalents; UB = upper bound.

*

Proportions are based on mixed model logistic regression equation.