TABLE 5.

AUC Values for ROC of Index Biomarkers (FC and FL) With Optimized Cutoffs Based on Youden’s Index and Their Corresponding Sensitivity and Specificity

		Nancy Index
	Optimized Cutoff	Positive ≥2	Negative ≤1	Sensitivity %*	Specificity %†	PPV %‡	NPV %§	Accuracy %║
FC	≥34.29 μg/g	93	18	65.0 [56.6–72.8]	78.3 [67.9–86.6]	83.8 [77.1–88.8]	56.5 [50.3–62.6]	69.9 [63.5–75.8]
	<34.29 μg/g	50	65
FL	≥5.85 μg/g	109	30	76.2 [68.4–82.9]	63.9 [52.6–74.1]	78.4 [72.9–83.1]	60.9 [52.7–68.6]	71.7 [65.3–77.5]
	<5.85 μg/g	34	53

*Sensitivity: proportion of patients correctly diagnosed as positive using the index test (TP/[TP + FN]).

†Specificity: proportion of patients correctly diagnosed as negative using the index test (TN/[TN + FP]).

‡Positive Predictive Value (PPV): proportion of patients correctly diagnosed as positive using the index test of all patients with a positive diagnosis using the index test (TP/[TP + FP]).

§Negative Predictive Value (NPV): proportion of patients correctly diagnosed as negative using the index test of all patients with a negative diagnosis using the index test (TN/[TN + FN]).

║Accuracy: proportion of patients correctly diagnosed as either positive or negative ([TP + TN]/[TP + FP + TN + FN]).

TP, true positive; TN, true negative; FP, false positive; FN, false negative.