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. 2022 Oct 26;1(5):pgac241. doi: 10.1093/pnasnexus/pgac241

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© The Author(s) 2022. Published by Oxford University Press on behalf of National Academy of Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 7. — Eisosome disruption activates sphingolipid biosynthesis and exocytosis. (A) The eisosome integrity is maintained by Pil1 and Lsp1. Sphingolipids, APC transporters, and transmembrane proteins Sur7 and Nec102 are enriched in eisosomes. (B) By disrupting eisosomes, sphingolipids, APC transporters, and transmembrane proteins Sur7 and Nce102 are redistributed within the plasma membrane. (C) The binding of Nce102 to TORC2 in MCT domains in the sphingolipid-depleted area activates sphingolipid signaling and biosynthesis. (D) Serine de novo synthesis and Gnp1-mediated serine import further promote sphingolipid biosynthesis. (E) The increased efficiency of sphingolipid production contributes to the formation of secretory vesicles in the trans-Golgi network. (F) Sphingolipids redistributed in the plasma membrane also promotes SNARE assembly during membrane fusion.