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. 2022 Aug 24;37(10):2334–2349. doi: 10.1093/humrep/deac183

Figure 2.

Figure 2.

Heterogeneity and transcriptomic changes in smooth muscle cells (SMCs) in MED12-variant positive leiomyomas compared to the myometrium. (A) Uniform Manifold Approximation and Projection on Principal (UMAP) components showing the clusters of 4650 SMCs. (B) UMAP showing that all cell clusters are present in the myometrium and MED12-variant positive leiomyomas. (C) Heatmap of the SMC clusters. The colored bar on the top represents the cluster number. Columns denote cells; rows denote genes. (D, E) In-situ images showing the validation of the SMC clusters in MED12-variant positive leiomyomas and myometrium. Scale bar is 50 µm. (F) Volcano plots showing the transcriptomic changes in the SMC clusters of MED12-variant positive cells compared to the myometrium. (G) Gene ontology (GO) analysis of DE genes showing at least 0.5-fold change in the MED12-variant positive leiomyomas as compared to the myometrium.