Table 1.
Study Characteristics12–39
| Author | Year | Location | Clinical Data Source | Journal | n | Genotyping Method | Genes Examined | No. Loci Examined | Abstract or Full Article |
|---|---|---|---|---|---|---|---|---|---|
| Ahmad | 2002 | United Kingdom | Prospective database | Gastroenterology | 158 | PCR sequence-specific primers | NOD2 | 3 | Article |
| Alvarez-Lobos | 2005 | Spain | Prospective database | Annals of Surgery | 170 | PCR sequence-specific primers | NOD2 | 3 | Article |
| Bhullar | 2014 | Australia | Retrospective | World Journal of Gastroenterology | 30 | dHPLC and direct sequencing | NOD2 | 4 | Article |
| Buning | 2004 | Germany | Retrospective | Alimentary Pharmacology and Therapeutics | 180 | PCR sequence-specific primers | NOD2 | 3 | Article |
| Burke | 2013 | Ireland | Prospective database | Annals of Surgery | 147 | SNP Assay | SMAD3 | 5 | Article |
| CTGF | |||||||||
| Chen | 2011 | NR | NR | — | 285 | SNP Assay | NOD2 | 4 | Abstract |
| ATG16L1 | |||||||||
| Fowler | 2014 | United States | Prospective database | Journal of Crohn’s and Colitis | 194 | Sequenom genotyping platform | NOD2, CARD9, ITLN1, ATG16L1, IRGM, LRRK2-MUC19, IL23R, JAK2, STAT3, TYK2, SMAD2, TNFSF15 | 25 | Article |
| Gathungu | 2018 | United States | Prospective database | World Journal of Gastroenterology | 412 | Illumina Golden Gate custom Immunochip array | NOD2, ATG16L1, IRGM, CARD9, XBP1, ORMDL, Others NR | NR | Article |
| Gerich | 2013 | NR | NR | — | 589 | 200k Immunochip platform | Multiple | NR | Abstract |
| Germain | 2016 | France | Prospective database | Surgery | 280 | SNPlex technology | CARD8 | 200 | Article |
| NAT2, Others NR | |||||||||
| Ghaly | 2016 | Australia | Prospective database | Inflammatory Bowel Disease | 309 | Taqman PCR | VDBP | 1 | Article |
| Laffin | 2018 | Canada | Prospective database | Inflammatory Bowel Disease | 191 | Illumina Goldengate assay platform | SMAD3, IL10RB, IL15RA, BACH2, IL12B, IL18RAP, IFNGR2, JAK2 | 8 | Article |
| Li | 2019 | United States | Prospective | PLoS One | 106 | Illumina Immunochip or Taqman Genotyping Assays | NOD2, ATG16L1, IRGM, CARD9, XBP1, ORMDL3 | 6 | Article |
| Liu | 2014 | United States | Retrospective | — | 178 | NR | NOD2, ATG16L1, Others NR | NR | Abstract |
| Liu | 2017 | United States | Retrospective | — | 98 | Japonica array | Multiple | 659,253 | Article |
| Maconi | 2009 | Italy | Prospective database | The American Journal of Gastroenterology | 253 | NR | NOD2 | 3 | Article |
| Martinek | 2015 | NR | Retrospective | Rozhledy v chirurgii | 76 | Primer-specific PCR | NOD2 | 3 | Article |
| Meijer | 2009 | Netherlands | Retrospective | Inflammatory Bowel Disease | 87 | PCR-RFLP and tetra primer ARMS PCR | MMP-TIMP | 1 | Article |
| Meresse | 2002 | NR | NR | Gut | 79 | Primer-specific PCR | IL10 promoter | 1 | Article |
| Naito | 2016 | Japan | Retrospective | — | 113 | Japonica array | Multiple | 659,253 | Abstract |
| Onnie | 2007 | United Kingdom | NR | European Journal of Gastroenterology & Hepatology | 630 | Taqman PCR | NOD2, IBD5 | 4 | Article |
| Potdar | 2019 | United States | Prospective database | Journal of Crohn’s and Colitis | 139 | Illumina Immuno-BeadChip | Multiple | NR | Article |
| Renda | 2008 | Italy | Prospective | American Journal of Gastroenterology | 182 | Allele-specific reverse dot-blot hybridization | NOD2 | 3 | Article |
| Sehgal | 2012 | United States | Retrospective | Diseases of the Colon & Rectum | 66 | DNA microarray | Multiple | 66 | Article |
| Seiderer | 2006 | Germany | Retrospective | Scandinavian Journal of Gastroenterology | 303 | Primer-specific PCR | NOD2 | 3 | Article |
| Siegel | 2011 | NR | Prospective | — | 376 | NR | Multiple | NR | Abstract |
| Van Dussen | 2014 | United States | Retrospective | Gastroenterology | 178 | Human OmniQuad SNP genotyping arrays and Immunochip | NOD2, Others NR | NR | Article |
| Yang | 2014 | Korea | Prospective database | Journal of Crohn’s and Colitis | 906 | Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-based system | TNFSF15 | 5 | Article |
dHPLC, denaturing high-performance liquid chromatography; NR, not reported; PCR, polymerase chain reaction; SNP, single nucleotide polymorphism.